TABLE 3.
Multivariable Cox models for locoregional recurrence, for entire cohort, and those without and with radiation
| Entire cohort (n = 2,212) | No-radiation cohort (n = 853) | Radiation cohort (n= 1,359) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n | Number of events |
HR (95 % CI) |
p value | n | Number of events |
HR (95 % CI) |
p value | n | Number of events |
HR (95 % CI) |
p value | |
| MRI obtained | 0.42 | 0.28 | 0.66 | |||||||||
| Yes | 581 | 37 | 1.18 (0.79–1.78) | 172 | 19 | 1.36 (0.78–2.39) | 409 | 18 | 1.14 (0.63–2.09) | |||
| No | 1,631 | 139 | 681 | 79 | 950 | 60 | ||||||
| Age at surgery | 0.98 (0.96–1.00) | 0.063 | 0.99 (0.97–1.01) | 0.39 | 0.96 (0.93–0.99) | 0.02 | ||||||
| Menopausal status | 0.48 | 0.85 | 0.64 | |||||||||
| Pre/perimeno pausal | 752 | 78 | 1.18 (0.75–1.83) | 250 | 36 | 1.06 (0.58–1.94) | 502 | 42 | 1.18 (0.59–2.33) | |||
| Postmenopausal | 1,460 | 98 | 603 | 62 | 857 | 36 | ||||||
| Family history | 0.5 | 0.92 | 0.3 | |||||||||
| Yes | 873 | 74 | 1.11 (0.82–1.5) | 340 | 41 | 1.02 (0.68–1.54) | 533 | 33 | 1.27 (0.81–2.01) | |||
| No | 1,339 | 102 | 513 | 57 | 826 | 45 | ||||||
| Presentation | 0.8 | 0.79 | 0.98 | |||||||||
| Radiologic | 2,017 | 155 | 774 | 85 | 1,243 | 70 | ||||||
| Clinical | 195 | 21 | 1.06 (0.67–1.68) | 79 | 13 | 1.09 (0.6–1.97) | 116 | 8 | 1.01 (0.48–2.13) | |||
| Margin status | < 0.001 | < 0.001 | 0.21 | |||||||||
| Negative | 1,849 | 131 | 734 | 72 | 1,115 | 59 | ||||||
| Close/positive | 363 | 45 | 1.96 (1.39–2.78) | 119 | 26 | 2.49 (1.56–3.97) | 244 | 19 | 1.41 (0.83–2.38) | |||
| Number of excisions | 0.2 | 0.41 | 0.36 | |||||||||
| ≤2 | 2,024 | 156 | 821 | 92 | 1,203 | 64 | ||||||
| ≥3 | 188 | 20 | 1.37 (0.85–2.2) | 32 | 6 | 1.43 (0.61–3.31) | 156 | 14 | 1.31 (0.73–2.37) | |||
| Radiation therapy | < 0.001 | |||||||||||
| Yes | 1,359 | 78 | NA | NA | ||||||||
| No | 853 | 98 | 2.05 (1.5–2.8) | |||||||||
| Endocrine therapy | 0.002 | 0.078 | 0.007 | |||||||||
| Yes | 526 | 27 | 147 | 13 | 379 | 14 | ||||||
| No | 1,686 | 149 | 1.9 (1.26–2.88) | 706 | 85 | 1.7 (0.94–3.05) | 980 | 64 | 2.24 (1.25–4.01) | |||
| Year of surgery | 0.38 | 0.73 | 0.26 | |||||||||
| 1997–2003 | 931 | 123 | 411 | 68 | 520 | 55 | ||||||
| 2004–2010 | 1,281 | 53 | 0.84 (0.58–1.23) | 442 | 30 | 0.92 (0.56–1.50) | 839 | 23 | 0.71 (0.39–1.29) | |||
Multivariable analysis performed controlling for age, menopausal status, family history of breast cancer, mode of presentation, margin status, number of excisions, radiation (for entire cohort), tamoxifen or other endocrine therapy, and year of surgery. Patients missing one or more covariate are excluded
HR hazard ratio, CI confidence interval