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. Author manuscript; available in PMC: 2015 Aug 12.
Published in final edited form as: Nat Struct Mol Biol. 2012 Aug 12;19(9):930–937. doi: 10.1038/nsmb.2356

Figure 6.

Figure 6

A model of H2B Tyr37 phosphorylation upstream of the major histone gene cluster Hist1 suppresses histone mRNA transcription. WEE1 phosphorylates H2B at Tyr37 upstream of histone cluster 1, Hist1. NPAT is excluded from binding to the Hist1 cluster because of its inability to recognize Tyr37-phosphorylated H2B, which in turn inhibits RNA polymerase II (Pol II) recruitment. Subsequently, HIRA is recruited to Tyr37-phosphorylated H2B, preventing NPAT rebinding and effectively resulting in the suppression of histone mRNA synthesis.