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. Author manuscript; available in PMC: 2016 Jan 26.
Published in final edited form as: Angew Chem Int Ed Engl. 2014 Dec 4;54(5):1466–1470. doi: 10.1002/anie.201409258

Figure 4.

Figure 4

Remodeling the glycocalyx of ESCs with highly sulfated HS induces accelerated self-renewal exit, neural lineage commitment, and differentiation into mature, neuronal cells. qRT-PCR quantification of mRNA levels for A) pluripotent marker NANOG, B) neuroectoderm marker SOX1, and C) neuronal marker TUJ1. Data points were normalized to the housekeeping genes GAPDH and SDHA for cross comparison and to the untreated condition at day 3 for data presentation. Values represent the mean ± S.E.M. (*P < 0.05, **P < 0.01 when compared to the untreated control at each time point) from two independent experiments.