Table 2.
Distribution of Pancreatic Cancer Cases, Controls, and Age-, Sex-Adjusted Odds Ratio (ASOR) Estimates for Selected Genetic Polymorphisms
| Genetic polymorphism | Cases (n = 455)
|
Controls (n = 893)
|
ASOR | 95% CI | ||
|---|---|---|---|---|---|---|
| No. | % | No. | % | |||
| MCPH1 (rs1057091) | ||||||
| CC | 215 | 48 | 419 | 47 | 1.00 (referent) | |
| TC | 201 | 45 | 389 | 44 | 1.00 | 0.78, 1.27 |
| TT | 31 | 7 | 77 | 9 | 0.80 | 0.51, 1.26 |
| FYN (rs1465061) | ||||||
| GG | 158 | 35 | 341 | 39 | 1.00 (referent) | |
| AG | 224 | 50 | 424 | 48 | 1.17 | 0.91, 1.51 |
| AA | 68 | 15 | 116 | 13 | 1.28 | 0.89, 1.83 |
| FYN (rs1465061) | ||||||
| AG +þ AA | 292 | 65 | 540 | 61 | 1.00 (referent) | |
| GG | 158 | 35 | 341 | 39 | 0.84 | 0.66, 1.07 |
| APC (rs2431238) | ||||||
| CC | 207 | 47 | 403 | 46 | 1.00 (referent) | |
| CT | 184 | 41 | 353 | 40 | 0.98 | 0.76, 1.26 |
| TT | 53 | 12 | 120 | 14 | 0.89 | 0.62, 1.29 |
| PRKCA (rs7342847) | ||||||
| CC | 181 | 40 | 349 | 40 | 1.00 (referent) | |
| CT | 208 | 46 | 406 | 46 | 1.00 | 0.78, 1.29 |
| TT | 62 | 14 | 128 | 15 | 0.96 | 0.67, 1.38 |
| NIN (rs10145182) | ||||||
| TT | 161 | 36 | 336 | 38 | 1.00 (referent) | |
| TA | 224 | 50 | 394 | 45 | 1.18 | 0.92, 1.53 |
| AA | 66 | 15 | 152 | 17 | 0.83 | 0.58, 1.19 |
| TopBP1 (rs10935070) | ||||||
| AA | 213 | 47 | 407 | 46 | 1.00 (referent) | |
| GA | 193 | 43 | 381 | 43 | 0.95 | 0.74, 1.21 |
| GG | 45 | 10 | 93 | 11 | 0.95 | 0.64, 1.41 |
| RIPK1 (rs12209182) | ||||||
| TT | 157 | 35 | 292 | 33 | 1.00 (referent) | |
| CT | 205 | 46 | 437 | 49 | 0.88 | 0.68, 1.14 |
| CC | 87 | 19 | 158 | 18 | 1.02 | 0.73, 1.42 |
| SNW1 (rs1477261) | ||||||
| TT | 284 | 71 | 593 | 68 | 1.00 (referent) | |
| AT | 107 | 27 | 263 | 30 | 0.85 | 0.65, 1.11 |
| AA | 11 | 3 | 18 | 2 | 1.31 | 0.61, 2.83 |
No., numbers may not add to total due to missing values; ASOR, age, sex-adjusted odds ratio; 95% CI, 95% confidence interval; MCPH1, microcephalin; FYN, tyrosine protein kinase fyn; APC, adenomatous polyposis coli; PRKCA, protein kinase C alpha; NIN, ninein; TopBP1, topoisomerase 2-binding protein; RIPK1, receptor-interacting serine/threonine-protein kinase 1; SNW1, SNW domain-containing protein.