Table 1.
Characteristics at the time of assessment of 156 perinatally HIV-infected South African children previously suppressed on ritonavir-boosted lopinavir (LPV/r)-based treatment and randomized to either maintain the LPV/r-based regimen or switch to a nevirapine (NVP)-based regimen
| Randomization group | |||||
|---|---|---|---|---|---|
| characteristic | Combined (n=156) |
Lpv/r (n=85) |
NVP (n=71) |
P-valuea | |
| Males | n(%) | 81 (51.9) | 41 (48.2) | 40 (56.3) | 0.313 |
| Age, years | Mean±SD | 5.1±0.8 | 5.2±0.8 | 5.0±0.8 | 0.095 |
| Total Time on ART, years | Mean±SD | 4.2±0.7 | 4.2±0.7 | 4.1±0.7 | 0.338 |
| Time Since Randomization, years | Mean±SD | 3.4±0.7 | 3.4±0.7 | 3.3±0.7 | 0.469 |
| Weight, kg | Mean±SD | 17.1±2.9 | 17.2±3.0 | 16.8±2.8 | 0.379 |
| Weight-for-Age z-score | Mean±SD | −0.67±1.0 | −0.67±0.9 | −0.66±1.0 | 0.912 |
| Height, cm | Mean±SD | 105.3±7.2 | 105.7±7.0 | 104.9±7.4 | 0.537 |
| Height-for-age z-score | Mean±SD | −0.98±1.1 | −1.02±1.0 | −0.93±1.2 | 0.575 |
| BMI, kg/m2 | Mean±SD | 15.3±1.5 | 15.4±1.6 | 15.2±1.4 | 0.529 |
| BMI-for-age z-score | Mean±SD | −0.1±1.0 | −0.09±1.0 | −0.11±1.1 | 0.884 |
| Blood Pressure, mmHg Systolic Diastolic |
Mean±SD |
98.5 ± 13.9 62.6 ± 11.6 |
99.6 ± 13.7 63.2 ± 12.3 |
97.0 ± 14.1 61.8 ± 10.6 |
0.294 0.464 |
| Viral Load, copies/mL <50 50–999 ≥1000 |
n (%) |
137 (87.8) 12 (7.7) 7 (4.5) |
72 (84.7) 8 (9.4) 5 (5.9) |
65 (91.6) 4 (5.6) 2 (2.8) |
0.450 |
| CD4 percent, % | Median (IQR) |
36.7 (32.7,41.3) |
35.9 31.2,40.6 |
37.2 33.0,41.5 |
0.185 |
| CD4 count, cells/mm3 | Median (IQR) |
1451 (1048, 1749) |
1356 (962, 1620) |
1480 (1174,1773) |
0.047 |
| LD Classification LD Possible LD No LD |
n (%) |
13 (8.3) 18(11.5) 125 (80.1) |
6 (7.1) 8 (9.4) 71 (83.5) |
7 (9.9) 10 (14.1) 54 (76.1) |
0.505 |
Abbreviations: SD, standard deviation; IQR, inter-quartile range
a
LPV/r- and NVP-groups were compared using the Wilcoxon rank sum test and t-test for continuous variables and chi-squared or Fisher's exact test for categorical variables