Table 3.

Body composition measures of 156 perinatally HIV-infected South African children suppressed on ritonavir-boosted lopinavir (LPV/r)-based treatment and randomized to either maintain the LPV/r-based regimen or switch to a nevirapine (NVP)-based regimen (Mean±SD)

		Randomization Group
Measure		combined (n=156)	LPV/r (n=85)	NVP (n=71)	P-value a
MUAC – Mid Upper Arm Circumference, cm		15.5±2.1	15.8±2.2	15.2±1.9	0.073
MTC – Mid Thigh Circumference, cm		29.7±3.4	30.1±3.8	29.3±2.9	0.143
MWC – Mid Waist Circumference, cm		51.1±3.7	51.4±4.0	50.8±3.5	0.325
MHC – Maximum Hip Circumference, cm		53.9±6.0	54.2±7.3	53.6±4.0	0.556
MWC – MHC Ratio		1.02±1.0	1.08±1.3	0.95±0.1	0.373
BSF – Bicep Skinfold, mm		5.29±1.7	5.67±1.8	4.84±1.5	0.002
TSF – Tricep Skinfold, mm		7.06±1.7	7.24±1.8	6.86±1.7	0.180
SSF – Subscapular Skinfold, mm		6.24±1.7	6.47±1.7	5.97±1.6	0.069
SISF – Suprailiac Skinfold, mm		6.40±2.6	6.58±2.8	6.18±2.2	0.329
USF – Umbilical Skinfold, mm		6.71±4.5	7.01±5.4	6.31±2.9	0.320
MTSF – Mid Thigh Skinfold, mm		9.80±3.2	10.4±3.3	9.1±3.0	0.018
SFS – Skinfold Sum, mm		41.3±10.8	43.0±11.1	39.0±10.1	0.031
%BF = %Body Fat by BIA		15.7±8.0	17.0±7.0	14.1±8.0	0.022
Extremity Fat Area
Arm	AFA - Arm Fat Area, cm2	5.5±1.9	5.8±2.1	5.2±1.7	0.078
	%AF - % of Fat in Arm	29.0±8.3	29.1±8.3	28.9±8.3	0.837
Leg	LFA - Leg Fat Area, cm2	14.8±5.8	15.7±6.0	13.6±5.3	0.023
	%LF - %of Fat in Leg	20.7±6.4	21.8±6.7	19.4±5.7	0.023
Regional Fat Proportions of Total Body Fat
Arm	[(BSF+TSF) / SFS]	0.30±0.04	0.30±0.05	0.30±0.04	0.734
Trunk	[(SSF +SISF+USF) / SFS]	0.46±0.06	0.45±0.06	0.47±0.05	0.114
Leg	[MTSF / SFS]	0.24±0.04	0.24±0.04	0.23±0.03	0.046
Trunk-Extremity Skinfold Ratios
Trunk-Arm	[(SSF+SISF) / (BSF+TSF+SSF+SISF)]	0.50±0.06	0.50±0.06	0.51±0.05	0.256
Trunk-Leg	[(SSF + SISF) / (MTSF + SSF+SISF)]	0.56±0.06	0.55±0.07	0.57±0.05	0.034

Abbreviations: SD, standard deviation

^aLPV/r- and NVP-groups were compared using t-tests