n
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Maximal number of kMTs |
2≤n
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Maximal number of kMTs that can be accommodated on a single |
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per kinetochore |
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kinetochore. n is proportional to the size of a kinetochore. |
p
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Association probability |
0≤p≤1/4 |
2×p is the association probability of a single microtubule to a free |
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kinetochore in each discrete time step. Upper limit of p is 1/4 |
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because total probability ≤1. |
q
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Dissociation probability |
0≤q≤1/2n
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Dissociation probability of a single kMT in each discrete time step. |
α
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Scaling factor of p
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0≤α≤1 |
Scaling applies to transitions from amphitelic (class 5) to merotelic |
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(class 4) states; reflecting the physical constraint imposed in |
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amphitelic states (meiosis I) or the back-to-back position of sister |
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kinetochores (mitosis). α=0 in mitosis for simplicity. |
β
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Scaling factor of q
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0≤β≤1 |
Scaling applies to transitions in/from amphitelic states (class 5); |
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reflecting the kMT stabilisation by tension. |
γ
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Scaling factor of p
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0≤γ≤1 |
Scaling applies to transitions from monotelic (class 2) to syntelic |
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(class 3) or merotelic (class 4) states in mitosis; reflecting the |
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biased orientation of sister kinetochores in monotelic states. |