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. 2015 Aug 12;13:65. doi: 10.1186/s12915-015-0172-y

Table 1.

Model parameters

Parameter for Range of values Biological meaning
n Maximal number of kMTs 2≤n Maximal number of kMTs that can be accommodated on a single
per kinetochore kinetochore. n is proportional to the size of a kinetochore.
p Association probability 0≤p≤1/4 p is the association probability of a single microtubule to a free
kinetochore in each discrete time step. Upper limit of p is 1/4
because total probability ≤1.
q Dissociation probability 0≤q≤1/2n Dissociation probability of a single kMT in each discrete time step.
α Scaling factor of p 0≤α≤1 Scaling applies to transitions from amphitelic (class 5) to merotelic
(class 4) states; reflecting the physical constraint imposed in
amphitelic states (meiosis I) or the back-to-back position of sister
kinetochores (mitosis). α=0 in mitosis for simplicity.
β Scaling factor of q 0≤β≤1 Scaling applies to transitions in/from amphitelic states (class 5);
reflecting the kMT stabilisation by tension.
γ Scaling factor of p 0≤γ≤1 Scaling applies to transitions from monotelic (class 2) to syntelic
(class 3) or merotelic (class 4) states in mitosis; reflecting the
biased orientation of sister kinetochores in monotelic states.