Table 3.
Correlation between the expression level of microRNAs miR-296-5p, miR-452, miR-183* and miR-200c and the clinical and pathological characteristics of the LSCC patients enrolled in the study
| Variable | Categories | Number of cases | miR-296-5p | miR-452 | miR-183* | miR-200c | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| Low | High | Low | High | Low | High | Low | High | |||
| n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | |||
| Age (years) | ≤60 years | 16 | 6 (35.3) | 10 (58.8) | 8 (47.1) | 8 (47.1) | 8 (47.1) | 8 (47.1) | 8 (50.0) | 8 (47.1) |
| >60 years | 18 | 11 (64.7) | 7 (41.2) | 9 (52.9) | 9 (52.9) | 9 (52.9) | 9 (52.9) | 8 (50.0) | 9 (52.9) | |
| p (2-sided) | NS | NS | NS | NS | ||||||
| Gender | Female | 4 | 2 (11.8) | 2 (11.8) | 2 (11.8) | 2 (11.8) | 2 (11.8) | 2 (11.8) | 2 (12.5) | 2 (12.5) |
| Male | 30 | 15 (88.2) | 15 (88.2) | 15 (88.2) | 15 (88.2) | 15 (88.2) | 15 (88.2) | 14 (87.5) | 15 (88.2) | |
| p (2-sided) | NS | NS | NS | NS | ||||||
| Smoking | No | 3 | 0 (0) | 3 (17.6) | 1 (5.9) | 2 (11.8) | 0 (0) | 3 (17.6) | 2 (12.5) | 1 (9.1) |
| Yes | 31 | 17 (100) | 14 (82.4) | 16 (94.1) | 15 (88.2) | 17 (100) | 14 (82.4) | 14 (87.5) | 16 (94.1) | |
| p (2-sided) | NS | NS | NS | NS | ||||||
| Tumor site* | Glottic | 27 | 15 (88.2) | 12 (70.6) | 14 (82.4) | 13 (76.5) | 14 (82.4) | 13 (76.5) | 14 (87.5) | 12 (70.6) |
| Supraglottic | 7 | 2 (11.8) | 5 (29.4) | 3 1 (7.6) | 4 (23.5) | 3 (17.6) | 4 (23.5) | 2 (12.5) | 5 (29.4) | |
| p (2-sided) | NS | NS | NS | NS | ||||||
| Tumor stage | I | 16 | 7 (41.2) | 9 (52.9) | 9 (52.9) | 7 (41.2) | 7 (41.2) | 9 (52.9) | 7 (43.8) | 9 (52.9) |
| II | 18 | 10 (58.8) | 8 (47.1) | 8 (47.1) | 10 (58.8) | 10 (58.8) | 8 (47.1) | 9 (56.2) | 8 (47.1) | |
| p (2-sided) | NS | NS | NS | NS | ||||||
| Radiosensibility | Sensivite | 14 | 11 (64.7) | 3 (17.6) | 8 (47.1) | 6 (35.3) | 9 (52.9) | 5 (29.4) | 7 (43.8) | 7 (41.2) |
| Resistant | 20 | 6 (35.3) | 14 (82.4) | 9 (52.9) | 11 (64.7) | 8 (47.1) | 12 (70.6) | 9 (56.2) | 10 (58.8) | |
| p (2-sided) | 0.01 | NS | NS | NS | ||||||
Italic value indicates statistical significance at p < 0.05.
p (Fisher’s exact); NS (p > 0.05).