Table 2.
Cumulative 0.3 M NaCl and water intake by satiated and normovolemic rats that received bilateral injections of muscimol or saline into the LPBN combined with injection of losartan, atropine or vehicle into the III-V.
| Treatment | 60 min | 120 min | 180 min | 240 min |
|---|---|---|---|---|
| 0.3 M NaCl intake (ml) | ||||
| Vehicle III-V + saline LPBN | 0.5 ± 0.4 | 0.6 ± 0.4 | 0.6 ± 0.4 | 0.6 ± 0.4 |
| Vehicle III-V + muscimol LPBN | 8.4 ± 4.2* | 23.7 ± 3.2* | 32.3 ± 2.5* | 32.3 ± 2.5* |
| Losartan III-V + muscimol LPBN | 2.7 ± 1.3 | 19.0 ± 3.1* | 27.6 ± 1.6* | 27.6 ± 1.6* |
| Atropine III-V + muscimol LPBN | 4.2 ± 1.6 | 23.0 ± 1.6* | 26.6 ± 2.3* | 26.6 ± 2.3* |
| Water intake (ml) | ||||
| Vehicle III-V + saline LPBN | 0.9 ± 0.4 | 1.1 ± 0.4 | 1.2 ± 0.4 | 1.2 ± 0.4 |
| Vehicle III-V + muscimol LPBN | 2.5 ± 0.6 | 14.2 ± 2.1* | 18.8 ± 2.4* | 18.9 ± 2.5* |
| Losartan III-V + muscimol LPBN | 1.3 ± 0.6 | 10.9 ± 2.2* | 16.3 ± 2.4* | 16.3 ± 2.4* |
| Atropine III-V + muscimol LPBN | 1.1 ± 0.5 | 12.9 ± 1.4* | 15.3 ± 1.6* | 15.4 ± 1.6* |
Results are reported as means ± SEM;
Different from vehicle III-V + saline LPBN; n = 8. Muscimol (0.5 nmol/0.2 μl); losartan (1 μg/0.1 μl); atropine (2 nmol/0.1 μl); vehicle (PBS, phosphate buffer saline).