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. 2015 Jun;15(2):145–153.

Table 2.

Vitamin D3 supplementation vs placebo on Bruininks-Oseretsky test of motor proficiency (BOTMP) outcomes.

n Baseline n 3-Month n 6-Month n 12-Month Fixed effect of randomization LSMean ± SEa Pa
Total Score
  - Placebo 27 72.4±0.8 26 72.7±1.0 26 71.2±1.2 26 71.5±1.1 71.6±0.4 0.041
  - Vitamin D 29 71.7±1.1 29 73.0±1.1 29 72.8±0.9 26 72.4±1.0 72.8±0.4
Subscales
Fine Motor Precision
 Line Drawing
  - Placebo 27 0.0±0.0 26 0.0±0.0 26 0.0±0.0 26 0.0±0.0 0.01±0.01 0.106
  - Vitamin D 29 0.0±0.0 29 0.0±0.0 29 0.1±0.0 26 0.0±0.0 0.04±0.01
 Fold paper
  - Placebo 27 11.4±0.2 26 11.3±0.4 26 11.0±0.5 26 10.2±0.6b 10.9±0.3 0.353
  - Vitamin D 29 11.4±0.2 29 11.3±0.2 29 11.4±0.3 26 10.8±0.5 11.2±0.3
Fine Motor Integration
 Copy Square
  - Placebo 27 4.9±0.1 26 4.9±0.1 26 5.0±0.0 26 5.0±0.0 4.9±0.03 0.460
  - Vitamin D 29 4.9±0.1 29 5.0±0.1 29 4.9±0.1 26 4.9±0.1 4.9±0.03
 Copy Star
  - Placebo 27 4.6±0.1 26 4.6±0.1 26 4.4±0.2 26 4.5±0.2 4.5±0.09 0.522
  - Vitamin D 29 4.7±0.2 29 4.7±0.2 29 4.3±0.3 26 4.3±0.3 4.5±0.09
Manual Dexterity
 Penny Transfer
  - Placebo 27 14.4±0.4 26 15.1±0.5 26 14.8±0.5 26 14.6±0.4 14.8±0.2 0.068
  - Vitamin D 29 14.6±0.6 29 15.3±0.6 29 15.8±0.6b 26 16.0±0.5b,c 15.4±0.2
Bilateral Coordination
 Jump in Place
  - Placebo 27 5.0±0.0 26 5.0±0.0 26 5.0±0.0 26 5.0±0.0 5.0±0.04 0.418
  - Vitamin D 29 4.8±0.2 29 5.0±0.0 29 4.8±0.2 26 5.0±0.0 5.0±0.04
Tap Feet & Fingers
 - Placebo 27 10.0±0.0 26 10.0±0.0 26 10.0±0.0 26 10.0±0.0 10.0±0.0 0.999
 - Vitamin D 29 10.0±0.0 29 10.0±0.0 29 10.0±0.0 26 10.0±0.0 10.0±0.0
Balance
 Line Walk
  - Placebo 27 5.9±0.1 26 5.9±0.1 26 6.0±0.0 26 6.0±0.0 6.0±0.01 0.176
  - Vitamin D 29 6.0±0.0 29 6.0±0.0 29 6.0±0.0 26 6.0±0.0 6.0±0.01
 One Leg Balance
  - Placebo 27 8.4±0.5 26 9.0±0.4b 26 8.3±0.5 26 8.0±0.6 8.1±0.2 0.258
  - Vitamin D 29 7.4±0.6 29 8.7±0.4b 29 8.3±0.4 26 8.0±0.5 8.4±0.2
Speed and Agility
 One Leg Hop
  - Placebo 27 31.5±1.36 26 31.3±1.0 26 30.6±1.2 26 31.3±1.2 31.6±0.6 0.090
  - Vitamin D 29 32.9±0.7 29 33.5±1.3 29 33.7±0.9c 26 33.8±1.0 33.1±0.6
Upper Limb Coordination
 Drop Catch
  - Placebo 27 4.9±0.1 26 5.0±0.0 26 5.0±0.0 26 5.0±0.0 5.0±0.02 0.823
  - Vitamin D 29 4.9±0.1 29 5.0±0.0 29 5.0±0.0 26 5.0±0.0 5.0±0.02
 Dribble Ball
  - Placebo 27 9.3±0.3 26 9.2±0.4 26 9.2±0.3 26 9.3±0.3 9.3±0.1 0.137
  - Vitamin D 29 9.3±0.4 29 9.3±0.3 29 9.7±0.2 26 9.8±0.2 9.5±0.1
Strength
 Pushup
  - Placebo 27 15.5±1.6 26 15.2±1.8 26 14.3±2.0 26 14.8±2.0 14.1±0.6 0.431
  - Vitamin D 29 13.6±1.7 29 14.3±1.5 29 14.1±1.3 26 14.0±1.2 14.8±0.6
 Situp
  - Placebo 27 18.9±1.3 26 16.8±1.7b 26 16.7±1.5b 26 18.7±1.5 16.6±0.5 0.088
  - Vitamin D 29 16.2±1.5 29 16.4±1.3 29 16.6±1.2 26 16.6±1.5 17.7±0.5
a

Results are the fixed effect of randomization group from multilevel regression models testing for persistence of response at 3-12 months based on untransformed data, also controlling for time of study visit and adjusting for baseline values; data are least-squares mean (LSMean) ± standard error (SE).

b

Significantly different from baseline mean within randomization group by paired t-test at P<0.05.

c

Significantly different from placebo mean within time of study visit by Student’s t-test at P<0.05.