Table II.
Parameter | Mean | % CV |
---|---|---|
aAUC(0-inf) (hr.nmol/L) | 21.6 | 34.9 |
bt ½ (hr) | 2.04 | 22.3 |
cCL (mL/min) | 1770 | 38.1 |
cCL (ml/min/m2) | 1250 | 42.5 |
dVss (L) | 287 | 45.4 |
dVss (L/m2) | 211 | 54.5 |
eVz (L) | 336 | 35.0 |
eVz(L/m2) | 239 | 37.1 |
N=15 except t1/2 N=25.
AUC(0-inf): Area under the concentration-time curve from time zero extrapolated to infinity;
t1/2: terminal half-life;
CL clearance
Vss: volume of distribution at steady state;
Vz: terminal phase volume of distribution