Table III.

Pharmacodynamic Parameters for TNF-alpha and IL-6 after Mifamurtide Infusion

Marker	Mifamurtide Infusion duration, min	aMean (%CV) bEmax (pg/mL)	Mean (%CV) cAUEC0-tlast (hr.pg/ml)	Median (range) TEmax (hr)
dTNF-alpha	60	412 (105)	2460 (82.1)	4.00 (2.00–4.00)
	30	582 (96.9)	2260 (86.0)	2.05 (1.00–4.00)
eIL-6	60	895 (94.1)	4650 (177)	4.00 (2.00–4.08)
	30	811 (112.0)	2200 (174)	4.00 (2.00–4.08)

^a%CV: coefficient of variation;

^bE_max: maximum pharmacodynamic effect;

^cAUEC_0-tlast: area under the effect the time curve from time 0 to time of last quantifiable effect;

^dTNF-alpha: tumor necrosis factor alpha;

^eIL-6: interleukin-6