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. Author manuscript; available in PMC: 2015 Aug 12.
Published in final edited form as: J Med Chem. 2013 Apr 26;56(9):3733–3741. doi: 10.1021/jm400288z

Figure 4.

Figure 4

Effect of ritonavir and compounds 1–3 on thermal stability (A) and the BFC hydroxylation activity of CYP3A4 (B). The denaturation and inhibitory assays were conducted as described in the Experimental Section. The Tm and IC50 values derived from the plots (A) and (B), respectively, are given in Table 1.