Fig. 1.

Correlation biosynthetic pathway of l-Arg and possible signaling cascade involved in the regulation of ODHC specific activity under Tween 40 addition by C. crenatum (Brief). Red thick arrows indicate increased fluxes by overexpressing the corresponding genes. Dot-dashed lines represent decreased or cut off fluxes by reducing relevant enzyme activity and knocking out relevant genes, respectively. G-6-P glucose-6-phosphate, ACT-CoA acetyl-CoA, Zwf glucose-6-phosphate dehydrogenase, Gnd 6-phosphogluconate dehydrogenase, ProB gamma-glutamyl kinase, PutP l-proline exporter, NCgl1221 glutamate exporter, LysE l-Arg and l-lysine exporter, N-ACTGLU N-acetylglutamate, N-ACTORN N-acetylornithine, argJBCDF-argGH, the gene clusters of l-Arg biosynthetic pathway, DtsR1 acetyl-CoA carboxylase, AccBc biotin carboxylase and biotin carboxyl carrier protein, PknG serine/threonine protein kinase, Ppp protein phosphatase, OdhI signal transduction protein, FHA-domain-containing protein, OdhA α-oxoglutarate dehydrogenase, LpdA dihydrolipoamide dehydrogenase, SucB dihydrolipoamide acetyltransferase.