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. 2015 Aug 12;10(8):e0135426. doi: 10.1371/journal.pone.0135426

Fig 8. Estradiol responsiveness of MCF-7 2D and 3D cultures.

Fig 8

2D and 3D samples are responsive to 17β-estradiol in a concentration-dependent manner, as evidenced by increased expression of GREB (A) and PGR (B) following 8 hours of exposure. MCF-7 monolayer and hydrogel culture respond to estradiol, with monolayer cultures responding more robustly. * = p≤0.05, ** = p≤0.01 p*** = p≤0.001, **** = p≤0.0001.