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. 2015 Aug 12;8:24. doi: 10.1186/s13040-015-0058-0

Table 2.

List of genetic association studies for chemotherapy-induced neuropathy in cancer patients, sorted by publication year and name of first author

Year First author Ethnicity Cancer type Sample size Phenotype Significant genes
2003 Aplenc R [41] W, AA, H Acute lymphoblastic leukemia 533 Peripheral neuropathy CYP3A4, CYP3A5
2004 Isla D [42] W Lung 62 Docetaxel-cisplatin-treated neurological None
2006 Lecomte T [43] W Gastrointestinal solid tumors 64 Oxaliplatin-related cumulative neuropathy GSTP1
2006 Sissung TM [44] W N/A 26 Paclitaxel-induced neuropathy ABCB1
2007 Gamelin L [45] W Colon, rectum 145 Oxaliplatin-induced neurotoxicity AGXT
2007 Marsh S [46] N/A Ovarian 914 Paclitaxel/docetaxel-induced neuropathy None
2007 Oldenburg J [47] W Testicular 238 Self-reported chemotherapy-induced long-term toxicities GSTP1
2007 Ruzzo A [48] W Colorectal 166 Oxaliplatin-induced neurotoxicity GSTP1
2008 Keam B [49] A Gastric 73 Peripheral sensory neuropathy None
2008 Pare L [50] W Colorectal 126 Cumulative oxaliplatin-induced neuropathy None
2008 Sissung TM [51] N/A Prostate 73 Docetaxel-induced neuropathy ABCB1
2009 Argyriou AA [52] W Colorectal 62 Oxaliplatin-induced peripheral neuropathy None
2009 Goekkurt E [53] W Gastric 134 Neurotoxicity GSTP1
2009 Green H [54] W Ovarian 38 Sensory/motor neuropathy None
2009 Kim HS [55] A Epithelial ovarian 118 Taxane/platinum- induced neurotoxicity ERCC1
2009 Kweekel DM [56] W Colorectal 91 Neurotoxicity None
2009 Mir O [57] W Breast, lung, prostate 58 Docetaxel(Taxotere)-induced peripheral neuropathy GSTP1
2009 Seo BG [58] A Gastric 94 Neuropathy None
2010 Antonacopoulou AG [59] W Colorectal 55 Chronic oxaliplatin-induced peripheral neuropathy ITGB3
2010 Boige V [60] W Colorectal 349 FOLFOX-induced severe neurologic toxicity None
2010 Chen YC [61] A Colorectal 166 Oxaliplatin-induced chronic cumulative neuropathy GSTP1
2010 Cho HJ [62] A Diffuse large B-cell lymphoma 94 Chemotherapy-related neurotoxicity None
2010 Inada M [63] A Colorectal 51 Oxaliplatin-induced peripheral neuropathy ERCC1, GSTP1
2010 Kanai M [64] A Colorectal 82 Early-onset oxaliplatin-induced neuropathy None
2010 Khrunin AV [65] W Ovarian 104 Cisplatin-based neuropathy GSTM1, GSTM3
2010 Li QF [66] A Gastric 92 Neurological toxicity GSTP1
2010 McLeod HL [67] W, A, AA, H Metastatic colorectal 520 Diarrhea, vomiting, paresthesia, febrile neutropenia and neutropenia GSTP1
2010 Ofverholm A [68] W Breast, ovarian 36 Occurrence and degree of neurotoxicity None
2010 Rizzo R [69] W Breast 95 Taxane-induced hypersensitivity and sensory neuropathy None
2011 Basso M [70] W Colorectal, pancreatic, bile ducts 40 Acute oxaliplatin neurotoxicity SK3
2011 Bergmann TK [71] W Ovarian 119 Sensory neuropathy None
2011 Bergmann TK [72] W Ovarian 92 Sensory neuropathy None
2011 Broyl A [73] W Multiple myeloma 369 Bortezomib/vincristine-induced peripheral neuropathy RHOBTB2, CPT1C, SOX8, caspase 9, ALOX12, IGF1R, SOD2, MYO5A, MBL2, PPARD, ERCC4, ERCC3, AURKA, MKI67, GLI1, DPYD, ABCC1
2011 Cibeira MT [74] W Multiple myeloma 28 Thalidomide-induced peripheral neuropathy GSTT1
2011 Corthals SL [75] W Multiple myeloma 238 Bortezomib induced peripheral neuropathy CYP17A1
2011 Favis R [76] W Myeloma 139 Bortezomib-induced peripheral neuropathy CTLA4, PSMB1, CTSS, GJE1, DYNC1I1, TCF4
2011 Hong J [77] A Colorectal 52 Sensory neuropathy GSTP1
2011 Johnson DC [78] W Multiple myeloma 1495 Thalidomide-related peripheral neuropathy ABCA1, ICAM1, PPARD, SERPINB2, SLC12A6
2011 Leskela S [79] W Lung, breast, ovary, uterus, head and neck 118 Neurotoxicity CYP2C8, CYP3A5
2011 Sucheston LE [80] W, AA Breast 888 Taxane-induced neurotoxicity FANCD2
2012 Baldwin RM [81] W, AA, A Breast 855 Paclitaxel induced peripheral sensory neuropathy FGD4, FZD3, EPHA5
2012 Braunagel D [82] W Acute myeloid leukemia 360 Cytarabine-induced neurotoxicity NME1
2012 Fung C [83] W, A, AA, H Testicular germ cell tumor 137 Cisplatin-induced neurotoxicity, peripheral neuropathy None
2012 Hasmats J [84] W Ovarian, lung, carcinoma in uteri/peritoneal/breast 94 Paclitaxel/carboplatin-induced neuropathy ABCA1
2012 Hertz DL [85] W, AA Breast 111 Peripheral neuropathy CYP2C8
2012 Leandro-Garcia LJ [86] W Ovary, lung, breast 214 Paclitaxel-induced peripheral neuropathy TUBB2A
2012 Won HH [87] A Colon 96 Severe oxaliplatin-induced chronic peripheral neuropathy TAC1, FOXC1, GMDS, ITGA1, PELO, ACYP2, TSPYL6, DLEU7, BTG4, POU2AF1, CAMK2N1, FARS2, LYRM4
2013 Argyriou AA [88] W Colorectal 200 Oxaliplatin-induced peripheral neuropathy SCN4A, SCN10A
2013 Bergmann TK [89] W Ovarian 241 Paclitaxel induced neuropathy None
2013 Cecchin E [90] W Colorectal 144 Oxaliplatin neurotoxicity ABCC1, ABCC2
2013 de Graan AJ [91] W Esophagus, ovary, cervix, endometrial, breast, lung, head/neck 261 Paclitaxel-induced neurotoxicity CYP3A4
2013 Hertz DL [92] W, AA Breast 209 Paclitaxel-induced neuropathy CYP2C8
2013 Kumamoto K [93] A Colorectal 63 Oxaliplatin-induced sensory peripheral neuropathy GSTP1, GSTM1
2013 Leandro-Garcia LJ [94] W Ovary, fallopian tube, peritoneum, lung, uterus, breast 144 Paclitaxel induced peripheral sensory neuropathy EPHA4, EPHA6, EPHA5, XKR4, LIMK2
2013 Lee KH [95] A Colon 292 Sensory neuropathy XRCC1
2013 Liu YP [96] A Gastric 126 Oxaliplatin-induced neurotoxicity GSTP1
2013 McWhinney-Glass S [97] N/A Ovarian 404 Platinum/taxane-induced neurotoxicity SOX10, BCL2, OPRM1, TRPV1
2013 Oguri T [98] A Colorectal 70 Oxaliplatin-induced chronic peripheral neurotoxicity ACYP2, FARS2, ERCC1, TAC1
2014 Abraham JE [99] W Breast 1303 Taxane-related sensory neuropathy ABCB1, TUBB2A, CYP2C8, ABCC2, CYP1B1, KIAA0146-PRKD, SLCO1B1, EPHA6
2014 Bhojwani D [100] N/A Acute lymphoblastic leukemia 369 Methotrexate-induced neurotoxicity ASTN2, PXDC1, IYD
2014 Custodio A [101] W Colon 206 Oxaliplatin-induced peripheral neuropathy CCNH, ABCG2
2014 Hertz DL [102] W, AA, A Breast 412 Paclitaxel-induced peripheral neuropathy CYP2C8, ABCG1
2014 Khrunin AV [103] W Ovarian 104 Cisplatin-based neurotoxicity None
2014 Lee SY [104] A Breast 85 Paclitaxel and gemcitabine combination chemotherapy neurotoxicity RRM1

W: White; A: Asian; AA: African American; H: Hispanic