Table 1.
Top upregulated genes after optic nerve crush
| Ensembl ID | Gene symbol | Gene name | Fold change | adjusted p-value | GO process or functiona |
|---|---|---|---|---|---|
| ENSDART00000081039 | sb:cb252 | sb:cb252 | 52.9 | 0.000065 | Associated with mitochondria |
| ENSDART00000025036 | gap43 | Growth associated protein 43 | 33.9 | 0.000161 | Tissue regeneration |
| ENSDART00000140944 | cremb | cAMP responsive element modulator b | 20.8 | 0.000065 | DNA-dependent transcription |
| ENSDART00000022060 | atf3 | Activating transcription factor 3 | 13.5 | 0.000279 | DNA-dependent transcription |
| ENSDART00000101970 | CU571382.1 | Uncharacterised protein | 10.7 | 0.000151 | |
| ENSDART00000126441 | lepa | Leptin a | 9.8 | 0.000161 | Nervous system development |
| ENSDART00000110691 | wnt6b | Wingless-type MMTV integration site family, member 6b | 14.6 | 0.000690 | wnt receptor signaling; neuron differentiation |
| ENSDART00000127420 | mdp1 | Magnesium-dependent phosphatase 1 | 6.6 | 0.000065 | Protein tyrosine phosphatase activity |
| ENSDART00000105597 | si:ch211-129c21.1 | si:ch211-129c21.1 | 9.7 | 0.000279 | Multicellular organismal development |
| ENSDART00000062845 | mmp9 | Matrix metalloproteinase 9 | 11.1 | 0.000558 | Proteolysis |
| ENSDART00000060765 | BX323876.3 | Brain natriuretic peptide-like | 9.7 | 0.000396 | Inflammatory response |
| ENSDART00000077197 | tmsb | Thymosin, beta | 11.1 | 0.000801 | Organization of cytoskeleton |
| ENSDART00000034377 | cpa5 | Carboxypeptidase A5 | 10.5 | 0.000690 | Proteolysis |
| ENSDART00000064789 | txn | Thioredoxin | 5.0 | 0.000065 | Cell redox homeostasis |
| ENSDART00000033494 | klf6a | Kruppel-like factor 6a | 4.7 | 0.000065 | Optic nerve formation |
| ENSDART00000064509 | stmn4l | Stathmin-like 4, like | 5.8 | 0.000161 | Regulation of microtubule (de)polymerization |
| ENSDART00000129989 | C14HXorf65 | Chromosome X open reading frame 65 | 5.0 | 0.000100 | |
| ENSDART00000144946 | adcyap1b | Adenylate cyclase activating polypeptide 1b | 7.3 | 0.000409 | Brain development |
| ENSDART00000020673 | f3a | Coagulation factor IIIa | 5.5 | 0.000161 | Blood coagulation; integral to membrane functioning |
| ENSDART00000133512 | fosl1b | FOS-like antigen 1b | 6.6 | 0.000409 | DNA-dependent transcription |
| ENSDART00000045410 | thy1 | Thy-1 cell surface antigen | 4.8 | 0.000161 | Organization of cytoskeleton; focal adhesion |
| ENSDART00000123518 | tuba1 | Tubulin, alpha 1 | 4.7 | 0.000161 | Optic nerve formation; regulation of microtubule processes |
| ENSDART00000101424 | nefma | Neurofilament, medium polypeptide a | 4.5 | 0.000161 | Organization of cytoskeleton |
| ENSDART00000121861 | prph | Peripherin | 10.0 | 0.002781 | Organization of cytoskeleton; tissue regeneration |
| ENSDART00000082153 | itga6a | Integrin, alpha 6a | 5.4 | 0.000409 | Cell adhesion membrane functioning; integrin signalling |
| ENSDART00000129227 | b3gnt2 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 | 4.8 | 0.000279 | Protein glycosylation |
| ENSDART00000141068 | sox11b | SRY-box containing gene 11b | 5.2 | 0.000381 | Neuron differentiation; response to wounding |
Ranked by combined –log10 p-value and ≥1.5 absolute fold change
aGO terms determined by ZFIN and Uniprot databases