Figure 2. Associations between serum inflammatory markers and cerebral vasoregulation in the T2DM group.

(A) Higher baseline HbA_1c is associated with greater increase in global cerebral vasoconstriction after 2-year follow-up, and (B) higher sICAM at baseline is associated with greater decrease in global vasoreactivity. Similar associations can be observed between the cerebral vasoregulations and serum sVCAM (C), cortisol (D), CRP (E), and IL-6 (F). Best fit = red solid line; confidence interval = red dashed lines; mean = blue dashed line. CRP = C-reactive protein; HbA_1c = glycated hemoglobin A_1c; IL-6 = interleukin 6; sICAM = soluble intercellular adhesion molecule; sVCAM = soluble vascular adhesion molecule; T2DM = type 2 diabetes mellitus.