Table 2.
Chromosomal gains in ductal carcinoma in situ (DCIS) with and without invasive cancer
| DCIS type | ||||||
|---|---|---|---|---|---|---|
| All patients | DCIS only | DCIS with invasive cancer | ||||
| N | (%) | N | (%) | N | (%) | |
| Total | 280 | (100.0) | 122 | (100.0) | 158 | (100.0) |
| 1q gains | ||||||
| No signal | 80 | (28.6) | 35 | (28.7) | 45 | (28.5) |
| No | 96 | (34.3) | 49 | (40.2) | 47 | (29.7) |
| Yes | 104 | (37.1) | 38 | (31.1) | 66 | (41.8) |
| 8q24 gains | ||||||
| No signal | 63 | (22.5) | 27 | (22.1) | 36 | (22.8) |
| No | 121 | (43.2) | 63 | (51.6) | 58 | (36.7) |
| Yes | 96 | (34.3) | 32 | (26.2) | 64 | (40.5) |
| 11q13 gains | ||||||
| No signal | 74 | (26.4) | 32 | (26.2) | 42 | (26.6) |
| No | 143 | (51.1) | 71 | (58.2) | 72 | (45.6) |
| Yes | 63 | (22.5) | 19 | (15.6) | 44 | (27.8) |
| HER2 gains | ||||||
| No | 188 | (67.1) | 84 | (68.9) | 104 | (65.8) |
| Yes | 92 | (32.9) | 38 | (31.1) | 54 | (34.2) |
| 1q and 8q24 gains | ||||||
| No signal | 94 | (33.6) | 43 | (35.2) | 51 | (32.3) |
| No | 133 | (47.5) | 63 | (51.6) | 70 | (44.3) |
| Yes | 53 | (18.9) | 16 | (13.1) | 37 | (23.4) |
| 1q and 11q13 gains | ||||||
| No signal | 108 | (38.6) | 46 | (37.7) | 62 | (39.2) |
| No | 138 | (49.3) | 67 | (54.9) | 71 | (44.9) |
| Yes | 34 | (12.1) | 9 | (7.4) | 25 | (15.8) |
| 1q and HER2 gains | ||||||
| No signal | 80 | (28.6) | 35 | (28.7) | 45 | (28.5) |
| No | 145 | (51.8) | 66 | (54.1) | 79 | (50.0) |
| Yes | 55 | (19.6) | 21 | (17.2) | 34 | (21.5) |
| 8q24 and 11q13 gains | ||||||
| No signal | 87 | (31.1) | 37 | (30.3) | 50 | (31.6) |
| No | 159 | (56.8) | 78 | (63.9) | 81 | (51.3) |
| Yes | 34 | (12.1) | 7 | (5.7) | 27 | (17.1) |
| 8q24 and HER2 gains | ||||||
| No signal | 63 | (22.5) | 27 | (22.1) | 36 | (22.8) |
| No | 163 | (58.2) | 74 | (60.7) | 89 | (56.3) |
| Yes | 54 | (19.3) | 21 | (17.2) | 33 | (20.9) |
| 11q13 and HER2 gains | ||||||
| No signal | 74 | (26.4) | 32 | (26.2) | 42 | (26.6) |
| No | 165 | (58.9) | 78 | (63.9) | 87 | (55.1) |
| Yes | 41 | (14.6) | 12 | (9.8) | 29 | (18.4) |
| 1q and 8q24 and 11q13 gains | ||||||
| No signal | 112 | (40.0) | 49 | (40.2) | 63 | (39.9) |
| No | 146 | (52.1) | 68 | (55.7) | 78 | (49.4) |
| Yes | 22 | (7.9) | 5 | (4.1) | 17 | (10.8) |
| 1q and 8q24 and HER2 gains | ||||||
| No signal | 94 | (33.6) | 43 | (35.2) | 51 | (32.3) |
| No | 150 | (53.6) | 66 | (54.1) | 84 | (53.2) |
| Yes | 36 | (12.9) | 13 | (10.7) | 23 | (14.6) |
| 1q and 11q13 and HER2 gains | ||||||
| No signal | 105 | (37.5) | 44 | (36.1) | 61 | (38.6) |
| No | 140 | (50.0) | 68 | (55.7) | 72 | (45.6) |
| Yes | 35 | (12.5) | 10 | (8.2) | 25 | (15.8) |
| 8q24 and 11q13 and HER2 gains | ||||||
| No signal | 113 | (40.4) | 44 | (36.1) | 69 | (43.7) |
| No | 167 | (59.6) | 78 | (63.9) | 89 | (56.3) |
| All four gains | ||||||
| No signal | 112 | (40.0) | 49 | (40.2) | 63 | (39.9) |
| No | 148 | (52.9) | 68 | (55.7) | 80 | (50.6) |
| Yes | 20 | (7.1) | 5 | (4.1) | 15 | (9.5) |
| Mutually exclusive categories | ||||||
| Unable to determine | 112 | (40.0) | 49 | (40.2) | 63 | (39.9) |
| No gains | 43 | (15.4) | 29 | (23.8) | 14 | (8.9) |
| 1q only | 31 | (11.1) | 15 | (12.3) | 16 | (10.1) |
| 8q24 only | 19 | (6.8) | 8 | (6.6) | 11 | (7.0) |
| 11q13 only | 8 | (2.9) | 4 | (3.3) | 4 | (2.5) |
| Two of three gains | 45 | (16.1) | 12 | (9.8) | 33 | (20.9) |
| All three gains | 22 | (7.9) | 5 | (4.1) | 17 | (10.8) |