Table 4.
Univariate and multivariable logistic regression analyses predicting invasive breast cancer among ductal carcinoma in situ (DCIS) cases
| Univariate | Multivariable (complete cases = 158) | Multiple imputation (all cases = 280) | ||||
|---|---|---|---|---|---|---|
| OR (95 % CI) | P value | OR (95 % CI) | P value | OR (95 % CI) | P value | |
| Gene category | 0.0027 | 0.0013 | 0.0001 | |||
| No gain | 1.00 | 1.00 | 1.00 | |||
| 1q only | 2.21 (0.85, 5.71) | 1.96 (0.68, 5.67) | 4.60 (1.77, 11.91) | |||
| 8q24 only | 2.85 (0.94, 8.66) | 4.23 (1.15, 15.50) | 4.24 (1.27, 14.11) | |||
| 11q13 only | 2.07 (0.45, 9.52) | 2.51 (0.42, 15.00) | 3.17 (0.65, 15.47) | |||
| Two of three gains | 5.70 (2.27, 14.27) | 9.07 (2.93, 28.11) | 7.91 (2.79, 22.41) | |||
| All three gains | 7.04 (2.16, 23.00) | 17.96 (3.92, 82.24) | 14.23 (3.56, 57.79) | |||
| Age at diagnosis, years | 0.015 | 0.0527 | 0.0253 | |||
| <40 | 3.38 (1.07, 10.64) | 3.60 (0.74, 17.50) | 4.60 (1.28, 16.49) | |||
| 40–49 | 0.69 (0.38, 1.23) | 0.46 (0.19, 1.12) | 0.71 (0.37, 1.38) | |||
| 50–64 | 1.00 | 1.00 | 1.00 | |||
| ≥65 | 0.57 (0.31, 1.08) | 0.70 (0.26, 1.89) | 0.68 (0.33, 1.39) | |||
| Race | 0.092 | 0.1478 | 0.3085 | |||
| Non-Hispanic (NH) white | 1.34 (0.50, 3.61) | 3.99 (0.70, 22.70) | 1.56 (0.51, 4.76) | |||
| NH Asian/Pacific Islander | 0.68 (0.23, 2.04) | 2.10 (0.31, 14.23) | 0.91 (0.25, 3.29) | |||
| Other | 1.00 | 1.00 | 1.00 | |||
| Hormone receptors | 0.4896 | 0.6824 | 0.4258 | |||
| ER and/or PR positive | 1.00 | 1.00 | 1.00 | |||
| Both ER and PR negative | 1.19 (0.73, 1.92) | 1.18 (0.53, 2.61) | 1.26 (0.71, 2.25) | |||
| Grade | 0.9263 | 0.8397 | 0.5300 | |||
| 1 | 1.00 | 1.00 | 1.00 | |||
| 2 | 1.13 (0.61, 2.08) | 0.93 (0.36, 2.40) | 0.73 (0.36, 1.52) | |||
| 3 | 1.12 (0.57, 2.18) | 0.73 (0.23, 2.29) | 0.62 (0.26, 1.46) | |||
| HER2 any gain | 0.5926 | 0.0102 | 0.0386 | |||
| No | 1.00 | 1.00 | 1.00 | |||
| Yes | 1.15 (0.69, 1.90) | 0.29 (0.12, 0.75) | 0.47 (0.23, 0.96) | |||
ER estrogen receptor, PR progesterone receptor