Fig 3. Expression of proteins involved in metabolism. All values are arbitrary units normalized to total protein levels (for phosphorylated proteins) or total protein staining as described in the methods.

Molecular weights are noted. Values are means±SEM. PKM2, pyruvate kinase M2 isoform; LDHA, lactate dehydrogenase A; ACC, acetyl-CoA carboxylase; p-ACC, phospho-ACC; PDH, pyruvate dehydrogenase; p-PDH, phospho-PDH; HXKII, hexokinase II; MCD, malonyl-CoA carboxylase; M-CPT1, Muscle carnitine palmitoyltransferase 1; PGC-1α peroxisome proliferator-activated receptor gamma coactivator 1 alpha; Glut4, glucose transporter 4; PDK2, pyruvate dehydrogenase kinase 2; PDK4, pyruvate dehydrogenase kinase 4. For immunoblots, Sham is the Cont-Sham group. n = 3 Sham, n = 5 Cont-TAC and n = 5 MycKO-TAC. *p<0.05 between indicated group versus Sham.