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. 2015 Jul 20;112(31):9763–9768. doi: 10.1073/pnas.1503497112

Fig. 2.

Fig. 2.

The effects of pH, adenosine and ATP on the mechanism of HIFI in term-pregnant rat myometrium. Repetitive brief episodes of (A-i) acidic (6.9) and (A-ii) alkalotic (7.9) external pH on myometrial contractility. Note that acidotic episodes could mimic the effects of hypoxia. Blocking the adenosine receptors with (B) nonspecific adenosine receptor blocker, 8-SPT and (C) with the specific A1 antagonist DPCPX, abolished the effects of hypoxic priming on contractions. (D) Three brief applications of ATPγS increased uterine contractile activity and (E) blocking the P2X7 receptors with A-438079 abolished the rebound increase in force induced by ATPγS episodes. When P2X7 receptors were blocked, little effect of hypoxia occurred with brief hypoxic episodes as in F-i compared with paired control (F-ii).