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Reproducible down-regulation of genes in the cholesterol biosynthetic pathway in Tet1/3 DKO E3.5 embryos compared with controls. Shown is the sequence of enzymes in the cholesterol biosynthesis pathway, indicating the degree of impaired expression based on RNA-seq data. The averaged normalized counts of three control and five Tet1/3 DKO embryos are plotted. Adjusted P values are shown at Right. Also see SI Appendix, Fig. S8.
