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Schematic of RNA recognition by the Nanoflare (Upper) and Sticky-flare (Lower). On recognition, the Nanoflare binds to RNA targets and releases a fluorophore-labeled oligonucleotide reporter (flare) to float freely in the cytoplasm. In contrast, flares from the Sticky-flare are longer and complementary to RNA targets, which allows them to bind transcripts and act as fluorescent labels for intracellular tracking.
