Table S1.
Fitted parameter values | Correlation between ΔωFB and ΔδFB | ||||||||||
Fit type | Global parameters, in addition to cM and cK | Local parameters, in addition to ΔωFB and R20 | No. parameters | Reduced χ2 | Average kON (× 107 M−1⋅s−1) | N-terminal average kOFF, s−1* | C-terminal average kOFF, s−1† | cM | cK | Slope | r‡ |
1§ | — | kON, kOFF | 132 | 2.097 | 1.71 ± 0.05 | 16.6 ± 0.7 | 12.7 ± 0.4 | 1.030 | 0.959 | 1.01 ± 0.08 | 0.973 |
2a | kON1(290–303), kON2(305–309) | kOFF | 122 | 2.114 | 1.75 ± 0.02 | 16.4 ± 0.6 | 12.8 ± 0.4 | 1.034 | 0.963 | 1.00 ± 0.07 | 0.974 |
2b | kON1(290–301), kON2(302–309) | kOFF | 122 | 2.117 | 1.65 ± 0.02 | 16.4 ± 0.6 | 12.8 ± 0.4 | 1.070 | 0.997 | 1.00 ± 0.08 | 0.973 |
3 | kON(290–309) | kOFF | 121 | 2.120 | 1.70 ± 0.04 | 16.3 ± 0.6 | 12.8 ± 0.4 | 1.039 | 0.967 | 1.00 ± 0.07 | 0.975 |
4a | kOFF1(290–303), kOFF2(305–309) | kON | 122 | 2.154 | 1.70 ± 0.06 | 15.8 ± 0.2 | 12.4 ± 0.2 | 1.037 | 0.966 | 1.01 ± 0.06 | 0.981 |
4b | kOFF1(290–301), kOFF2(302–309) | kON | 122 | 2.149 | 1.81 ± 0.06 | 15.8 ± 0.2 | 12.6 ± 0.2 | 1.027 | 0.954 | 0.97 ± 0.07 | 0.975 |
5a | kON(290–309), kOFF1(290–303), kOFF2(305–309) | — | 111 | 2.168 | 1.73 ± 0.04 | 15.8 ± 0.2 | 12.5 ± 0.2 | 1.036 | 0.964 | 0.99 ± 0.06 | 0.983 |
5b | kON(290–309), kOFF1(290–301), kOFF2(302–309) | — | 111 | 2.167 | 1.80 ± 0.04 | 16.0 ± 0.2 | 12.5 ± 0.2 | 1.021 | 0.950 | 0.97 ± 0.07 | 0.973 |
6a | kON1(290–303), kON2(305–309), kOFF1(290–303), kOFF2(305–309) | — | 112 | 2.171 | 1.65 ± 0.04 | 15.8 ± 0.6 | 12.6 ± 0.7 | 1.056 | 0.983 | 1.00 ± 0.06 | 0.981 |
6b | kON1(290–301), kON2(302–309), kOFF1(290–301), kOFF2(302–309) | — | 112 | 2.175 | 1.75 ± 0.04 | 16.1 ± 0.7 | 12.6 ± 0.7 | 1.040 | 0.967 | 0.97 ± 0.08 | 0.969 |
7 | kOFF(290–309) | kON | 121 | 2.380 | 2.02 ± 0.09 | 13.7 ± 0.1 | 0.989 | 0.917 | 0.93 ± 0.04 | 0.992 | |
8 | kON(290–309), kOFF(290–309) | — | 110 | 2.409 | 2.18 ± 0.06 | 13.6 ± 0.1 | 0.960 | 0.889 | 0.91 ± 0.03 | 0.993 |
kOFF1 or the average of kOFF for residues 290–301.
kOFF2 or the average of kOFF for residues 302–309.
Correlation coefficient.
The results of this type of fit are shown in Fig. 2.