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. 2015 Jul 20;112(31):9614–9619. doi: 10.1073/pnas.1512799112

Table S1.

Variants of the subglobal fits to the two-state model in which clusters of residues are constrained to have the same values of kON and kOFF

Fitted parameter values Correlation between ΔωFB and ΔδFB
Fit type Global parameters, in addition to cM and cK Local parameters, in addition to ΔωFB and R20 No. parameters Reduced χ2 Average kON (× 107 M−1⋅s−1) N-terminal average kOFF, s−1* C-terminal average kOFF, s−1 cM cK Slope r
1§ kON, kOFF 132 2.097 1.71 ± 0.05 16.6 ± 0.7 12.7 ± 0.4 1.030 0.959 1.01 ± 0.08 0.973
2a kON1(290–303), kON2(305–309) kOFF 122 2.114 1.75 ± 0.02 16.4 ± 0.6 12.8 ± 0.4 1.034 0.963 1.00 ± 0.07 0.974
2b kON1(290–301), kON2(302–309) kOFF 122 2.117 1.65 ± 0.02 16.4 ± 0.6 12.8 ± 0.4 1.070 0.997 1.00 ± 0.08 0.973
3 kON(290–309) kOFF 121 2.120 1.70 ± 0.04 16.3 ± 0.6 12.8 ± 0.4 1.039 0.967 1.00 ± 0.07 0.975
4a kOFF1(290–303), kOFF2(305–309) kON 122 2.154 1.70 ± 0.06 15.8 ± 0.2 12.4 ± 0.2 1.037 0.966 1.01 ± 0.06 0.981
4b kOFF1(290–301), kOFF2(302–309) kON 122 2.149 1.81 ± 0.06 15.8 ± 0.2 12.6 ± 0.2 1.027 0.954 0.97 ± 0.07 0.975
5a kON(290–309), kOFF1(290–303), kOFF2(305–309) 111 2.168 1.73 ± 0.04 15.8 ± 0.2 12.5 ± 0.2 1.036 0.964 0.99 ± 0.06 0.983
5b kON(290–309), kOFF1(290–301), kOFF2(302–309) 111 2.167 1.80 ± 0.04 16.0 ± 0.2 12.5 ± 0.2 1.021 0.950 0.97 ± 0.07 0.973
6a kON1(290–303), kON2(305–309), kOFF1(290–303), kOFF2(305–309) 112 2.171 1.65 ± 0.04 15.8 ± 0.6 12.6 ± 0.7 1.056 0.983 1.00 ± 0.06 0.981
6b kON1(290–301), kON2(302–309), kOFF1(290–301), kOFF2(302–309) 112 2.175 1.75 ± 0.04 16.1 ± 0.7 12.6 ± 0.7 1.040 0.967 0.97 ± 0.08 0.969
7 kOFF(290–309) kON 121 2.380 2.02 ± 0.09 13.7 ± 0.1 0.989 0.917 0.93 ± 0.04 0.992
8 kON(290–309), kOFF(290–309) 110 2.409 2.18 ± 0.06 13.6 ± 0.1 0.960 0.889 0.91 ± 0.03 0.993
*

kOFF1 or the average of kOFF for residues 290–301.

kOFF2 or the average of kOFF for residues 302–309.

Correlation coefficient.

§

The results of this type of fit are shown in Fig. 2.