Fig. 3.

Computational model examining the effect of axo-axonic synapse position on APs. (A) GABAergic synapses were evenly spaced along the axon starting at 2 μm from the soma in the control and “AIS distal” scenario. In the third scenario the synapses were displaced distally together with the AIS. (B) APs elicited by a current pulse in the three scenarios. (C) Peak AP voltage (Left) and difference in peak voltage compared with control (Right), for varying GABA_AR conductance. (D) Time to AP peak (Left) and difference in time to peak compared with control (Right). (E) Current threshold in response to a short, 3-ms current injection (Left) and difference in current threshold compared with control (Right).