Table 1.

Derived Tinaja MC4R mutations are prevalent in independently derived cave populations and present in surface fish populations

Cave population	Genotype
	s/s	c/s	c/c
Pachón	2	3	4
Molino*	0	0	9
Arroyo	0	0	7
Yerbaniz	0	0	9
Piedras	0	0	1
Micos	0	0	1
Japonese	0	0	5
Sabinos	0	0	1
Tinaja	0	0	9
Surface	107	6	1

C = Tinaja allele and S = surface allele in multiple wild cave and surface populations.

^*Except for Molino, frequencies represent all three described mutations. For Molino, residue V162 is the surface variant (compare also Fig. S1 and Fig. 3A).