Fig. 6.

MAC internalization occurs in human coronary arteries and is required for NIK stabilization in vivo. (A) SCID/beige mice bearing human coronary arteries were treated with PRA serum depleted of IgG (IgG⁻ serum) or PRA serum. Grafts were harvested at 18 h after injection and analyzed by immune-EM (n = 2 pairs of mice). (Scale bar: 10 nm.) (B and C) Grafts were harvested at 18 h after PRA injection (B), and MFI of the indicated stains was analyzed by IF (C) (n = 5 pairs of mice). (D) Schematic of events triggered by MACs to activate noncanonical NF-κB. Quantitation of the data is represented as mean ± SEM. *P < 0.05. (Scale bars: 200 μm.)