Fig. 3.
Silencing of a small subset of neurons is sufficient to produce and retrieve fear memory. (A) Arch-EYFP expression in a small number of auditory cortical neurons. (B) Behavioral procedure for C and D. (C) Mice showed freezing behavior in response to light delivery to the conditioned, but not the unconditioned side. Each plot denotes the averaged value during light ON epochs (n = 12, *P = 0.033, t11 = 2.4, paired t test). (D) Relationship between the freezing time in response to light delivery on the conditioned side and the proportion of mCherry+ neurons in that area.