Fig. 4.

Mice can find rewards based on optogenetic silencing. (A) Green light delivery to the auditory cortex indicated the direction of the baited arm of the T-maze. (B) Mice acquired the ability to find reward based on the presence or absence of optogenetic silencing (Arch, n = 10; EYFP, n = 8; ***P < 0.001 versus chance, Z-test for a proportion). (C) In Light ON trials, green light was delivered only at the start box. (D) Brief light delivery before the trial was sufficient for the mice to find the reward (Arch, n = 10; EYFP, n = 8; *P < 0.05, ***P < 0.001 versus chance, Z-test for a proportion). Error bars indicate mean ± SEM.