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. Author manuscript; available in PMC: 2015 Aug 12.
Published in final edited form as: Mol Cancer Ther. 2015 Feb 23;14(3):769–778. doi: 10.1158/1535-7163.MCT-14-0926

Figure 5.

Figure 5

AR inhibition decreases migration and invasion of TNBC cells. A, cellular morphology (200×) of BT549 cells transduced with a nontargeting control (shNEG) compared with a shRNA targeting AR (shAR15) in 3D Matrigel culture. Arrow, stellate cellular morphology. B, migration scratch wound assay of TNBC cell lines with AR knockdown under serum-starved conditions. C, scratch wound assay of TNBC AR knockdown cell lines invading through Matrigel. D, changes in cellular morphology of BT549 cells treated with vehicle (Veh) or enzalutamide (ENZ) in 3D Matrigel culture (200×). E, migration (left) and invasion (right) assays of BT549 cells treated with or without enzalutamide. **, P < 0.01; ***, P < 0.001 by the t test at the final time point.