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. 2015 Sep 1;405(1):82–95. doi: 10.1016/j.ydbio.2015.06.017

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© 2015 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Fig. 1 — Major cardiovascular defects in Chd7^fl/fl;Mesp1-Cre embryos. (A) At E15.5, Chd7^fl/fl;Mesp1-Cre embryos showed severe oedema (arrow) and/or haemorrhaging compared to littermate Chd7^fl/fl controls. (B) Normal great vessel configuration was seen in Chd7^fl/fl embryos, whilst 21% of Chd7^fl/fl;Mesp1-Cre embryos showed interrupted aortic arch type B (IAA-B) when examined at E15.5 (star). India ink injection was used on the Chd7^fl/fl;Mesp1-Cre embryo shown here to better visualise the great vessels. (C) Ink injection at E10.5 was used to visualise the developing left and right 3rd, 4th and 6th pharyngeal arch arteries (PAAs) in Chd7^fl/fl (top panel) and Chd7^fl/fl;Mesp1-Cre (bottom panel) embryos. All Chd7^fl/fl;Mesp1-Cre embryos examined showed normal PAA development (n=14). Scale bars represent 1 mm (A), 0.5 mm (B) or 0.2 mm (C). rsc/lscindicates right/left subclavian artery; rcc/lcc, right/left common carotid artery; aa, aortic arch; oft, outflow tract; ra/la, right/left atrium; rv/lv, right/left ventricle.