Fig 4. HNSCC cells harboring an endogenous PTPRD mutation (PE/CA-PJ49) are more sensitive to the STAT3 pathway inhibitor JSI-124 relative to representative PTPRD WT HNSCC cells (PE/CA-PJ34clone12).

Cells were treated with increasing concentrations of JSI-124 for 24 hours followed by MTT assay. The experiment was performed three times with similar results.