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. Author manuscript; available in PMC: 2016 Nov 1.
Published in final edited form as: Neurosci Biobehav Rev. 2015 Feb 12;58:186–210. doi: 10.1016/j.neubiorev.2015.02.003

Figure 10.

Figure 10

Intensity, frequency, and site dependency of STN stimulation evoked striatal DA release of the urethane anesthetized rat. (A.) The optimal current intensity for STN stimulation was 300 μA, with the stimulation evoked DA response falling off at 600 μA and greater. (B.) The optimal frequency for STN stimulation was 50 Hz, with the stimulation evoked DA response falling off at 75 Hz and greater. (C.) Prolonged STN stimulation evoked a transient response that peaked within 20 applied pulses (red line), as compared to a 10-fold greater and more sustained DA response to stimulation of the medial forebrain bundle (MFB) (blue line). INSET: DA release evoked by stimulation of the MFB (blue line) was significantly faster at onset compared to STN stimulation when viewed on the same scale as the STN response (red line).