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. Author manuscript; available in PMC: 2016 Nov 1.
Published in final edited form as: Neurosci Biobehav Rev. 2015 Feb 12;58:186–210. doi: 10.1016/j.neubiorev.2015.02.003

Figure 9.

Figure 9

(A.) Represetative example of medial forebrain bundle stimulation-evoked (20 pulses at 100 Hz applied every 10 min) striatal DA release in a urethane anesthetized intact rat and a rat sustaining neurotoxic 6-OHDA lesioning of the nigrostriatal dopaminergic pathway before and following systemic injection of L-DOPA (100 mg/kg i.p.). Note the recovery of stimulated DA release to 100% baseline levels of evoked striatal DA release following administration of L-DOPA in lesioned animals. (B.) Mean ± SEM time courses of effects of L-DOPA injections, compared to saline administration, on striatal DA release in intact and lesioned rats before and following systemic injection of L-DOPA. Solid and dashed blue lines: intact mice that received L-DOPA and saline, respectively. Percentage changes refer to intact pre-saline treated mice.