Fig 1. Immunization scheme and delayed acquisition after intrarectal repetitive SIVmac251 low dose challenges.
(A) Immunization and challenge schedule. O = oral; IN = intranasal; IT = intratracheal; IM = intramuscular; IR = intrarectal. Dosages and further details are provided in on-line Methods. (B) No difference in SIV acquisition between all immunized macaques and current controls (n = 12). (C) No difference in SIV acquisition rate in gp120- and gp140-immunized macaques and current controls. (D) Similar acquisition rate in historical (n = 53) and current controls. (E) Delayed SIV acquisition in all immunized macaques compared to combined controls (n = 65). (F) Delayed SIV acquisition in all immunized females (n = 32) compared to combined control females (n = 24) but not (G) in all immunized males (n = 16) compared to combined control males (n = 41). (H) Delayed SIV acquisition in gp120-immunized females compared to combined control females. (I) Trend for delayed SIV acquisition in gp140-immunized females compared to combined control females. No difference in SIV acquisition rate in gp120-immunized males (J) and gp140-immunized males (K) compared to combined control males.