Fig 5. Schematic illustrating the effect of multiple generation exposure to increased dietary fat and carbohydrate on changes in fasting plasma glucose levels with ageing.

The effect of the 21% is evident form the initial generation exposed to the diet and remains unchanged following multiple generations on the diet. Exposure to the 5% diet leads to few or no effects in the initial generation exposed, however following a sustained exposure to the diet for three generations, a similar profile is reached to that of the 21% exposed group.