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. 2015 Jul 31;56(8):553–564. doi: 10.4111/kju.2015.56.8.553

Table 3. Molecular biomarkers in bladder cancer.

Class Marker Prognostic value
Cell cycle regulators p21 [55] Higher stage, recurrence, all-cause mortality
p27 [56] Higher grade, cancer-specific mortality
Ki67 [33] Recurrence, progression
Cyclin D [55] Low grade, low stage, recurrence
Cyclin E [55] Low stage, recurrence, cancer-specific mortality
Apoptosis Survivin [32] Recurrence, cancer-specific mortality, all-cause mortality
Bcl2 [8] Recurrence, cancer-specific mortality
Caspase-3 [56] Recurrence, cancer-specific mortality
Angiogenesis Micro-vessel density [57] Recurrence, all-cause mortality
VEGF [58] Microvessel density, high grade, recurrence
FGFR3 [60] Recurrence, cancer-specific mortality
Tumor suppressor genes p53 [53] Higher stage, recurrence, progression, cancer-specific and all-cause mortality
pRb [54] Higher stage, recurrence, progression, cancer-specific and all-cause mortality
Proto-oncogenes & oncogenes EGFR [64] Higher grade, progression, all-cause mortality
Her-2 Neu [64] Recurrence, metastasis, cancer-specific mortality
FGFR3 [60] Low grade, low stage, recurrence and progression
Miscellaneous GSTT1 [4] Recurrence, progression, cancer-specific mortality
NOS & PPAR [65] Progression, cancer-specific mortality
HMOX1 [66] Higher grade, recurrence and progression