Fig. 3.

The Gene Expression Data Query Form (http://www.informatics.jax.org/gxd) features two search tabs: Standard and Differential Expression. The Standard Search (above) provides the most flexibility, allowing querying of expression data using the parameters of most interest. The Genes section allows searching by a specific gene or for a set of genes based on their function [as defined by Gene Ontology terms (Gene Ontology Consortium 2015)]; their association with mouse phenotypes [as defined by Mammalian Phenotype Ontology terms (Smith and Eppig 2012)]; or their association with human diseases [as defined by Online Mendelian Inheritance in Man (OMIM) terms (Amberger et al. 2015)]. The Genome location section makes it possible to limit expression searches to genes located in a particular chromosomal region, which is useful when hunting for candidate genes. The Anatomical structure or stage section allows searching for expression data in specific anatomical structures and/or developmental (Theiler) stages or ages. Anatomical searches take advantage of the hierarchy of the anatomy ontology, returning annotations to substructures as well as to the structure itself. The Mutant/wild-type section can be used to limit the searches to expression data from wild-type mice or from specific mutants. The Assay types section allows for the selection of desired expression data types. Auto-fill functionality helps to find appropriate search terms. The illustrated search is “Which canonical Wnt signaling genes have been studied in the kidney?” Figure 5 shows the corresponding search results pages