Table 3.
Association Between Week-1 Metabolic Response and Objective Response by RECIST v1.0
| Week-1 Metabolic Response | Total | Objective Response |
Predictive Value |
||||
|---|---|---|---|---|---|---|---|
| No. of Responders (%) | No. of Nonresponders (%) | PPV (%) | 95% CI | NPV (%) | 95% CI | ||
| Cohort 1 | |||||||
| PMR | 28 | 19 (68) | 9 (32) | 68 | 51 to 85 | 91 | 74 to 100 |
| SMD/PMD | 11 | 1 (9) | 10 (91) | ||||
| Unknown | 1 | 0 (0) | 1 (100) | ||||
| Total | 40 | 20 (50) | 20 (50) | ||||
| Cohort 2 | |||||||
| PMR | 21 | 7 (33) | 14 (67) | 33 | 13 to 53 | 91 | 79 to 100 |
| SMD | 22 | 2 (9) | 20 (91) | ||||
| Unknown | 2 | 1 (50) | 1 (50) | ||||
| Total | 45 | 10 (22) | 35 (78) | ||||
NOTE. Patients were tabulated by objective response (responder v nonresponder) and metabolic response (partial metabolic response [PMR] v stable metabolic disease [SMD]/progressive metabolic disease [PMD]). Objective response was based on RECIST v1.0 (responder: confirmed complete response or partial response; nonresponder: unconfirmed partial response, stable disease, progressive disease, or unknown). Metabolic response was based on European Organisation for Research and Treatment of Cancer criteria.
Abbreviations: NPV, negative predictive value; PPV, positive predictive value.