Table A6.
Association Between Week-8 Metabolic Response and Objective Response by RECIST v1.0
| Week-8 Metabolic Response | Total | Objective Response No. (%) |
Predictive Values |
||||
|---|---|---|---|---|---|---|---|
| Responder | Nonresponder | PPV (%) | 95% CI | NPV (%) | 95% CI | ||
| Cohort 1 | |||||||
| PMR | 27 | 19 (70) | 8 (30) | 70 | 53 to 88 | 100 | 100 to 100 |
| SMD/PMD | 7 | 0 (0) | 7 (100) | ||||
| Unknown | 6 | 1 (17) | 5 (83) | ||||
| Total | 40 | 20 (50) | 20 (50) | ||||
| Cohort 2 | |||||||
| PMR | 18 | 7 (39) | 11 (61) | 39 | 16 to 61 | 88 | 74 to 100 |
| SMD | 24 | 3 (13) | 21 (88) | ||||
| Unknown | 3 | 0 (0) | 3 (100) | ||||
| Total | 45 | 10 (22) | 35 (78) | ||||
NOTE. Patients were tabulated by objective response (responder v nonresponder) and metabolic response (partial metabolic response [PMR] v stable metabolic disease [SMD]/progressive metabolic disease [PMD]). Objective response was based on RECIST v1.0 (responder: confirmed complete response or partial response; nonresponder: unconfirmed partial response, stable disease, progressive disease, or unknown). Metabolic response was based on European Organisation for Research and Treatment of Cancer criteria.
Abbreviations: NPV, negative predictive value; PPV, positive predictive value.