Garella et al. [14] |
Providence, RI, USA, 1973 |
156 dogs, low, normal, or high bicarbonate concentration |
Preexisting plasma bicarbonate concentration influences the apparent bicarbonate volume of distribution |
|
Arieff et al. [16] |
San Francisco, USA, 1982 |
Dogs with phenformin-induced lactic acidosis |
Bicarbonate reduced portal vein blood flow, cardiac output, and pH in liver and erythrocytes |
|
Benjamin et al. [17] |
New York, USA, 1994 |
Experimental hemorrhagic shock in dogs, compared bicarbonate versus hypertonic saline versus Carbicarb |
Bicarbonate moderately increased blood pressure, cardiac index, oxygen delivery, and oxygen consumption but not better than hypertonic saline |
|
Goldsmith et al. [18] |
London, UK, 1997 |
Human leukocytes in vitro |
Sodium bicarbonate caused intracellular acidification |
|
Levraut et al. [19] |
Nice, France, 2001 |
Human hepatocytes in vitro |
Sodium bicarbonate decreases intracellular pH, and intracellular pH changes are linked to pCO2 in surrounding fluid |
|
Nielsen et al. [20] |
Copenhagen, Denmark, 2002 |
31P-magnetic resonance spectroscopy in skeletal muscle of healthy subjects |
Bicarbonate administration attenuated the reduction of intracellular muscle pH |
|
Valenza et al. [15] |
Milan, Italy, 2012 |
32 Sprague Dawley rats in four groups |
Bicarbonate corrected acidosis in normoxic, normotensive rats, but effects of bicarbonate on pH different in rats receiving transient versus persistent lactic acid infusion |