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. 2015 Jul 30;2015:605830. doi: 10.1155/2015/605830

Table 2.

Laboratory studies evaluating bicarbonate administration in sepsis or acidosis. Studies are listed in chronological order, based on year of publication.

Reference Country, year Study design Results
Garella et al. [14] Providence, RI, USA, 1973 156 dogs, low, normal, or high bicarbonate concentration Preexisting plasma bicarbonate concentration influences the apparent bicarbonate volume of distribution

Arieff et al. [16] San Francisco, USA, 1982 Dogs with phenformin-induced lactic acidosis Bicarbonate reduced portal vein blood flow, cardiac output, and pH in liver and erythrocytes

Benjamin et al. [17] New York, USA, 1994 Experimental hemorrhagic shock in dogs, compared bicarbonate versus hypertonic saline versus Carbicarb Bicarbonate moderately increased blood pressure, cardiac index, oxygen delivery, and oxygen consumption but not better than hypertonic saline

Goldsmith et al. [18] London, UK, 1997 Human leukocytes in vitro Sodium bicarbonate caused intracellular acidification

Levraut et al. [19] Nice, France, 2001 Human hepatocytes in vitro Sodium bicarbonate decreases intracellular pH, and intracellular pH changes are linked to pCO2 in surrounding fluid

Nielsen et al. [20] Copenhagen, Denmark, 2002 31P-magnetic resonance spectroscopy in skeletal muscle of healthy subjects Bicarbonate administration attenuated the reduction of intracellular muscle pH

Valenza et al. [15] Milan, Italy, 2012 32 Sprague Dawley rats in four groups Bicarbonate corrected acidosis in normoxic, normotensive rats, but effects of bicarbonate on pH different in rats receiving transient versus persistent lactic acid infusion