Fig. 1.
Calculation of doubling time and adjustment of anti-CMV treatment.
An algorithm was constructed to detect the first positive sample of the infectious episode, termed V1 and corresponding to the time t1. The highest sample within 14 days of the V1 sample was then detected; this sample is called Vpeak, and it corresponded to the time tpeak. The doubling time could then be calculated.
The proportion of time used for calculation of doubling time covered with anti-CMV treatment was determined based on data on anti-CMV treatment collected from patient files.