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. 2015 May 12;2(7):706–712. doi: 10.1016/j.ebiom.2015.05.012

Table 1.

Genetic risk score for premature discontinue of efavirenz.

Score 1 (reference score): Homozygous for the reference allele in all 3 genes
Score 2: Homozygous for the reference allele for CYP2B6, and 1 to 4 LOF/DOF alleles for CYP2A6 and CYP3A4
Score 3: 1 LOF/DOF allele for CYP2B6 but no LOF/DOF allele for CYP2A6 and CYP3A4
Score 4: 1 LOF/DOF allele for CYP2B6 and 1 to 4 LOF/DOF alleles for CYP2A6 and CYP3A4
Score 5: 2 LOF/DOF alleles for CYP2B6 but no LOF/DOF allele for CYP2A6 and CYP3A4
Score 6: 2 LOF/DOF alleles for CYP2B6 and 1 to 4 LOF/DOF alleles for CYP2A6 and CYP3A4