Fig. 3.

Mutations in some representative genes. Schematic representations of proteins encoded by the genes are shown. Numbers refer to amino acid residues. Mutations found in HPR and CR patients are shown in red and black, respectively. Each “+” corresponds to an independent, mutated tumor sample, and “*” indicates a nonsense (truncating) mutation. Mutations underlined with a same-colored line are found in the same patient. (A): The five genes which were mutated in > 10% tumor samples in both regions. (B): Representative five genes whose mutation rates in HPR lung cancer were significantly higher than in CR NSCLCs. (C): Mutations in TMEM132C which were mutated in 6/79 (7.59%) HPR NSCLCs and 12/85 (14.12%) CR lung cancers (p = 0.182).