Table 3.

Summary of neuroanatomical associations of humour processing in the patient cohort.

Contrast	Region	Side	Cluster (voxels)	Peak coordinates (mm)			Z score	P value	Group
				x	y	z
Humour detection: familiar scenariosa	Fusiform gyrus	L	59	−40	−30	−29	3.87	.048	Combined
	Fusiform gyrus	L	597	−40	−30	−29	4.25	.013	bvFTD
	T – O junction	L	419	−57	−54	1	4.06	.041
Humour detection: novel scenariosb	Ant MTG/STS	R	315	68	−15	−12	4.47	.008	bvFTD

All statistically significant associations between grey matter volume and humour parameters are summarised (see also Fig. 3). Local maxima coordinates are in MNI standard stereotactic space. All contrasts were significant at threshold p < .05 after family-wise error correction within the pre-specified anatomical small volume of interest. ‘Combined’ refers to common associations across both patient groups. Contrasts index patient performance on aspects of humour processing, as follows (see also Table 2).

^aGrey matter volume positively correlated with humour detection accuracy in familiar scenarios.

^bGrey matter volume positively correlated with humour detection accuracy in novel scenarios. Ant, anterior; bvFTD, behavioural variant of frontotemporal dementia; MTG, middle temporal gyrus; STS, superior temporal sulcus; T-O, temporo-occipital.