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. 2015 Aug 13;6:168. doi: 10.3389/fphar.2015.00168

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Copyright © 2015 Fatima, Cohen, Sukumar, Sissung, Schooley, Haigney, Claycomb, Cox, Dalgard, Bates and Flagg.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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HDAC inhibitors (HDIs) significantly increase SUR2 expression in HL-1 cells but not MIN6 cells. (A) HDAC inhibition with trichostatin A (TSA) caused a marked, dose-dependent, increase in SUR2 expression, while SUR1 expression is essentially unchanged (n = 3–10). (B) Like TSA (30 ng/mL), another HDI, romidepsin (5 nM), caused an increase in SUR2 expression in HL-1 cardiomyocytes with little change in SUR1. In contrast, neither TSA nor romidepsin affected SUR subunit expression in MIN6 pancreatic β-cells (n = 5).