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. 2015 Aug 13;6:168. doi: 10.3389/fphar.2015.00168

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Copyright © 2015 Fatima, Cohen, Sukumar, Sissung, Schooley, Haigney, Claycomb, Cox, Dalgard, Bates and Flagg.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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BeadArray profiling reveals a potential role for cholesterol and SREBP. (A) Venn diagram illustrating the number of genes specifically changed (≥4-fold increase or decrease). Analysis using GATHER software (Chang and Nevins, 2006) focused on the common gene set that was altered by both compounds. (B) Shown are the BeadArray signal intensities of seven transcripts that are included in the top gene ontology hit (GO0006936: muscle contraction). (C) Expression changes were confirmed in 5 of 7 genes tested by qRT-PCR. (D) Annotation of common gene set for transcription factor binding sites (TRANSFAC, v8.2) revealed a putative role for SREBP in 60 out of 171 genes annotated.