Table 2.
Polymorphisms | Drug response |
CYP3A5*1 | Increased PIs clearance |
CYP2B6 rs3475274, rs28399499 | Increased EFV and NVP plasma concentrations |
ABCB1 3435C > T | Better viral responses to EFV exposure |
ABCB1 rs1045642 (3435T > C) | CT/CC genotype associated with higher CD4 count in EFV, 3TC, NVP containing regimen |
PIs: Protease inhibitors; NVP: Nevirapine; EFV: Efavirenz.