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Pharmacogenetics and highly active antiretroviral therapy response
| Polymorphisms | Drug response |
| CYP3A5*1 | Increased PIs clearance |
| CYP2B6 rs3475274, rs28399499 | Increased EFV and NVP plasma concentrations |
| ABCB1 3435C > T | Better viral responses to EFV exposure |
| ABCB1 rs1045642 (3435T > C) | CT/CC genotype associated with higher CD4 count in EFV, 3TC, NVP containing regimen |
PIs: Protease inhibitors; NVP: Nevirapine; EFV: Efavirenz.
