Table II.
Final log-rank test results for the risks of lymph node metastasis, primary site recurrence, distant metastasis and disease-specific death in oral squamous cell carcinoma.
| Log-rank (Mantel-Cox) | Lymph node metastasis | Primary site recurrence | Distant metastasis | Disease-specific deathd |
|---|---|---|---|---|
| Gene expression ratios | ||||
| CDK2/CDKN1A | – | 0.019 | 0.017 | 0.002 |
| CDK1/CDKN1B | 0.008 | 0.047 | – | 0.041 |
| CCNE1/CDK2 | 0.002 | – | 0.012 | 0.005 |
| Integrin gene expression ratios | ||||
| ITGB4/JUP | – | – | 0.008 | – |
| ITGA3/CD9 | 0.005 | – | – | 0.011 |
| Clinicopathological parameters | ||||
| Size, >20 mma | 0.047 | 0.057 | – | – |
| Positive marginb | 0.002 | <0.001 | – | 0.001 |
| Invasive histologyc | 0.005 | 0.032 | 0.051 | 0.001 |
Major width of the tumor was categorized into >20 and ≤20 mm.
Histological tumor positiveness of the surgical margin.
Histopathological classification of oral squamous cell carcinoma [Yamamoto et al (9)].
Fatality from uncontrollable oral squamous cell carcinoma. Data are P-values. Continuous variables of gene expression ratios are categorized according to the cut-off points introduced by receiver operating characteristic curves of distant metastasis for CDK2/CDKN1A, CDK4/CDKN2A and ITGB4/JUP, of lymph node metastasis for CDK1/CDKN1B, CCNE1/CDK2 and ITGA3/CD9. CDK, cyclin-dependent kinase; CCN, cyclin.